Molecular Classification of Low-Grade Diffuse Gliomas
نویسندگان
چکیده
منابع مشابه
Diffuse low-grade gliomas
Description : Diffuse low-grade gliomas (WHO grade II) are a sub-group of rare and heterogeneous primary brain tumors that usually occur in young patients living a normal life until the onset of a first seizure. A good understanding of the natural history of these gliomas namely: their steady progression, infiltration along white matter fibers and especially the risk of malignant transformation...
متن کاملMolecular classification of diffuse gliomas.
Diffuse gliomas are the most common primary brain tumors. The current World Health Organization (WHO) brain tumor classification (2007) uses exclusively morphological criteria to separate diffuse gliomas into three main subtypes: astrocytoma, oligodendroglioma, and mixed oligoastrocytoma. The WHO defines mixed oligoastrocytomas as tumors with dual glial cellular components (astrocytic and oligo...
متن کاملThe etiopathogenesis of diffuse low-grade gliomas.
The origins of diffuse low-grade gliomas (DLGG) are unknown. Beyond some limited data on their temporal and cellular origins, the mechanisms and risk factors involved are poorly known. First, based on strong relationships between DLGG development and the eloquence of brain regions frequently invaded by these tumors, we propose a "functional theory" to explain the origin of DLGG. Second, the bio...
متن کاملMuch debated controversies of diffuse low-grade gliomas
Duffau and colleagues present a comprehensive and provocative review of the concepts of surgical and medical management of adult diffuse low-grade gliomas (DLGG). The review takes a very strong position, which will likely generate debate and stimulate much discussion regarding the establishment of guidelines for care of patients with DLGG. Here we provide a counterpoint to summarize the perspec...
متن کاملCurrent Management of Adult Diffuse Infiltrative Low Grade Gliomas.
Diffuse infiltrative low grade gliomas (LGG) account for approximately 15 % of all gliomas. The prognosis of LGG differs between high-risk and low-risk patients notwithstanding varying definitions of what constitutes a high-risk patient. Maximal safe resection optimally is the initial treatment. Surgery that achieves a large volume resection improves both progression-free and overall survival. ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2010
ISSN: 0002-9440
DOI: 10.2353/ajpath.2010.100680